Dynamine ™ – a new pre workout neuroactivating stimulant, “caffeine without side effects”
Compound Solutions considered one of the leading companies in the market, known for innovation, efficiency and commitment to research. Most likely, you probably used several patented components of this company before, but didn’t even know it. The company is responsible for PeakO2, Carb10 and another long-acting “neuroactivator” called TeaCrine® (Theacrine).
While TeaCrine® became very popular last year or so, the company began to work hard on the next effective neuroactivator or stimulant, which was due to the known problems that DMAA and DMGA had. We think this will be one of the best neuroactivating stimulants of 2020.
This new neuroactivating ingredient is Dynamine ™, and we have ALL the information you were looking for about this next generation stimulator.
Dynamine (Methyliberin) is a caffeine derivative developed by Compound Solutions that is positioned as the faster-acting Theacrine.
What is dynamine and why is it best pre workout?
Dynamine ™ is the faster and more complex version of Theacrine (also developed by Compound Solutions), which is more focused on the use of pre-workout supplements, game supplements or even energy drinks, while Theacrine® is best suited for heavy nootropic formulas.
Both theacrine and dynamine are caffeine derivatives – the king of all stimulants.
If you want to know what Dynamine ™ is, then put on your lab coats because it will be complex information.
Dynamine ™ – Methyliberin, a derivative of caffeine and a relative of theacrine. Dynamine and theacrine are classified as methylurates, which differ from methylxanthines such as caffeine, theobromine, etc. We will see that these differences are small, but, you know, small differences in structure lead to BIG differences in the effect on the body.
The official molecular formula of Dynamine ™ is 2-methoxy-1,7,9-tetramethyl acid, and the TeaCrine® formula is 1,3,7,9-tetramethyl acid. In general, it happens that the methyl group at the “3-position” of the theacrine molecule is thrown out of the ring and transferred to one of the oxygen (2-oxo) in the pyrimidine ring. Therefore, a methoxyl group is formed, which is generally more favorable for solubility in fats.
This group makes the molecule less hydrophilic, which is good for us, because less hydrophilic molecules cross membranes more easily (for example, the blood-brain barrier). This methoxy group can also change the way Dynamine interacts with the receptors and enzymes in your brain.
Sources of best energy supplement Dynamine: Natural pre workout
Dynamine ™ is naturally found in the same plant sources as theacrine, theobromine, theophylline, xanthine, caffeine, paraxanthine and all purine alkaloids. This plant source containing all these wonderful compounds is Robusta coffee. It should not be confused with arabica, the type of coffee that most people consume daily. Please note that Dynamine (and theacrine) is also present in arabica, but not in such quantities as in robusta.
Dynamine ™ is found in Assamese tea (Camellia assamica var. Kucha) and in small amounts in cocoa and yerba-mat, as well as in Cupuaçu (pronounced ku-pu-a-su), but NOT in black or green tea (Camellia sinensis), like many other compounds.
For those who don’t know, Theobroma grandiflorum is a cocoa-like tree that grows in the Amazon in Brazil, Peru, Bolivia and Colombia. Its fruits are similar to cocoa beans, they have a white pulp containing alkaloids in high concentrations.
Explicit Compliance Case
All these sources are an important step to comply with the requirements of the DSHEA (Food Additives Act), as there are no arguments against natural origin, since Dynamine is clearly an “integral part” of several “plants” (words whose definitions are still discussed in the case of DMAA) As we will see later, Compound Solutions insists on adding Dynamine to the GRAS list (a list of substances recognized as completely harmless) and is funding a lot of research to ensure that it is truly safe.
How does natural pre workout dynamine work?
Meet Dr. Hector Lopez, Lead Researcher of Dynamine and Theacrine.
Do a search on Methyliberin and you will quickly realize that there are no studies directly with this compound. The small resources you will find will discuss the breakdown of caffeine or bioactive coffee compounds. Interestingly, the main search results [encompassing TeaCrine® (theacrine) and Dynamine ™ (methylliberin)] are actually the results of the early work of co-authors Tim Siegenfuss, PhD, FISSN, Sean Wells, MPH, RD, FISSN and Hector L. Lopez, MD, CSCS, FAAPMR, FISSN, arising from their first-ever study of these “methylurates” with the participation of people in 2010-2011. Dynamine ™ and TeaCrine® are trademarks and are protected by numerous international patents, pending priority confirmation serial number 61/903, 362 and US patent 9,468,645; Compound Solutions
Acquaintance with Compound Solutions
Only when we spoke with Compound Solutions CEO Matt Titlow and Hector L. Lopez, MD, CSCS, FAAPMR, FISSN did we really learn what this compound is and how it works in the body. The two creators of Dynamine ™ (and TeaCrine®) were kind enough to tell how this amazing mix works.
Metiluratı – TeaCrine® (Theacrine) and Dynamine ™ (Methyliberin) – These are an extremely rare class of biologically active ingredients that are neuro-activators but do not affect heart rate, blood pressure or vasoconstriction(press response). In other words, Dynamine ™ (and TeaCrine®) stimulate the central nervous system without affecting the cardiovascular system.
Compound Solutions sponsors Dynamine research.
These compounds have less effect on your adrenal glands than caffeine and other stimulants. Along with reduced adrenal stress, Dynamine ™ and TeaCrine® also lead to a decrease in cortisol, norepinephrine, etc.
Compound Solutions suggested that the reason for the differences in action and pharmacodynamics of Dynamine (fast acting, with high effect), compared with Theacrine, is due to its slightly different structure. The “game with a methyl group” allowed the Dynamine molecule to penetrate the blood-brain barrier (BBB) faster, which leads to faster effects, possibly more powerful activation of dopamine receptors and signaling from other neurotransmitters (norepinephrine, serotonin and GABA).
Dynamine is similar to Theacrine, but the displacement of the methyl group significantly affects its ability to cross the blood-brain barrier.
It is also hypothesized that, similarly to Theacrine, it is an allosteric modulator of adenosine receptors (a weak inhibitor). Allosteric inhibition is similar to using a “key” (Dynamine) to a place remote from the main place of the “lock” (adenosine receptor). Caffeine, on the contrary, orthostatically blocks the entire “lock”, connecting with its main receptor site. As a result, weak allosteric inhibition is probably responsible for the lack of addiction and tachyphylaxis characteristic of Theacrine and Dynamine.
The first work with the participation of people shows that the onset of effect (ENV = energy, mood, attention) occurs more quickly. The onset of action is about 10-15 minutes, the peak occurs after 45-60 minutes, and then a decline occurs within 2.5-3 hours.
Is it the healthiest pre workout?
Compound Solutions at Dynamine sees an excellent “neuroactivator” that delivers robust cognitive enhancement.
In other words, the effects that consumers expected from Theacrine can be more clearly obtained from Dynamine, namely a quick and pronounced action.
In essence, Dynamine ™ enhances cognitive properties, so its effect is similar to the usual “caffeine charge”, but in fact it does not affect the cardiovascular system or adrenal glands. Methyluric acids (i.e. methylurates) differ from methylxanthines (caffeine, paraxanthine, xanthine). A slight difference, consisting in the position of one oxo group, affects the above parameters of the cardiovascular system.
It also means that Dynamine ™ and Theacrine® should NOT affect sleep. This was shown in preliminary studies when the compounds were taken late in the evening and PSQI (Pittsburgh Sleep Quality Index) was measured.
How to use healthiest pre workout? Dosage and combination with jym pre workout
The company Compound Solutions said that the “golden mean” of doses of Dynamine is in the range of 100-200 mg. Studies are currently underway to determine the “ideal” dose based on its independent use, as well as in combination with all types of other CNS activating compounds (more on this below!).
Safety of pre workout: dose-response study
Compound Solutions is currently researching genotoxicity, chromosomal aberrations, and mutagenicity, which the company says looks promising. A number of other rat studies are also being conducted (LD50 study), a dose-response study (a 14-day study … a sufficient period of time for rats), and a much longer classical toxicological study to determine NOAEL (a dose that does not have a clear undesirable effect), which It is important information for determining the dose of GRAS (a dose recognized as completely harmless) and meeting the criteria for “defined no harm under the conditions of intended use”.
In addition, three human clinical trials are being conducted in parallel with rat complex toxicity studies. Compound Solutions hopes to receive a dose of GRAS as the “final rule” of the FDA in accordance with OECD / GLP recommendations … this is a higher safety standard than even NDI (the new food ingredient)!
Pre Workout Combinations: Dynamine + Caffeine, Caffeine + Theacrine + Dynamine
Caffeine + Dynamine
As mentioned above, caffeine just makes everything better (except perhaps sleep). Therefore, Dynamine goes well with caffeine. In any case, 200-300 mg of caffeine and 100-200 mg of Dynamine are ideally combined and improve the effect of “ENV”, which you get from a new cognitive amplifier.
Caffeine + Theacrine + Dynamine
Combine caffeine, Theacrine and Dynamine for a stunning combo of immediate and lasting energy, mood and focus.
This combination is just magical. It really gives you the best of all connections. Thanks to the combination of caffeine and Dynamine, you will get immediate energy, attention and alertness. And when you add Theacrine® to the mixture, you get a combination for long-term maintenance of this state.
According to early reports from alpha and beta testers, as well as preliminary research, the combination of caffeine + Dynamine ™ + Theacrine® is fantastic! It seems to provide a “stable full-spectrum effect” all day long!
In combination with other synergistic ingredients (tyrosine, cholinergics, caffeine, rhodiola, bacopa, lion’s mane (Hericium erinaceus) and other central nervous system activating ingredients) you can take a lower dose, most likely in the range of 50-100 mg.
Pre workout supplements containing Dynamine ™
Dynamine ™ is still a new ingredient, and only a few companies use it in their formulas. Here is a list of companies that have already included it in their existing products, or will include in their next release of their pre-workout supplements.
- Inspired Nutraceuticals DVST8 White Cut (2018 version)
- Performax Labs StimMax
- ATP Nutrition Perform Kinetics V2
Dynamine is one step higher than caffeine, which we fully enjoy! It acts faster than Theacrine, but does not lead to the accumulation of water.
Initial Dynamine ™ Overview / First Impression
Initially, the PricePlow team tried it and noticed pleasant effects from the very beginning – it is clearly faster and causes more “sensations” than Theacrine. This is a review of the first impression after a single dose.
After additional use, the prospects seem very favorable. In fact, Dynamine causes the effects that we expected from Theacrine. You begin to feel it faster, and this is usually what users want.
We believe this is the perfect complement to caffeine, especially for those whose coffee “just doesn’t work anymore.”
Is Dynamine the best pre workout 2019?
When TeaCrine® appeared, it was a breakthrough ingredient for long-lasting, clean energy. But ordinary fans of pre-workout supplements who start training 60 minutes or less after ingestion, during the actual workout, never received the benefits of boosting energy and attention from the ingredient they were hoping for.
That’s when Dynamine ™ comes in. It offers the same end effects, but provides them much faster, making it ideal for use in pre-workout supplements.